Investing.com -- The biotechnology sector continues to offer compelling investment opportunities in 2026, with several companies poised for significant growth according to Bank of America analysts. From groundbreaking treatments to commercial launches, these four biotech stocks stand out as BofA’s top picks for the year ahead.
BofA has identified companies with strong commercial momentum and important upcoming catalysts that could drive substantial value creation. These selections span from established players expanding their portfolios to emerging companies with breakthrough therapies.
See how Wall Street analysts are valuing these stocks with InvestingPro’s full ratings, price targets, and earnings models -
Argenx remains one of BofA’s top biotech picks for 2026, with analysts maintaining a Buy rating and setting a price objective of $1,006 (€863). The firm expects continued strong commercial performance of Vyvgart in generalized myasthenia gravis (gMG) and chronic inflammatory demyelinating polyneuropathy (CIDP). The prefilled syringe approval, geographic expansion, and accumulating real-world data should sustain momentum. BofA models peak sales of $6.8 billion in gMG ($493/share) and $4.5 billion in CIDP ($303/share). Four Phase 3 readouts and updates from early-stage pipeline programs in 2026 provide multiple opportunities for upside.
Argenx announced that the U.S. Food and Drug Administration accepted for priority review its application to expand Vyvgart’s use for another form of generalized myasthenia gravis. The company also revealed a leadership transition plan, with current COO Karen Massey set to be promoted to CEO.
KalVista Pharmaceuticals earned a spot among BofA’s top 2026 picks with a Buy rating and $30 price objective. Analysts maintain a bullish outlook on Ekterly, the first approved oral on-demand therapy for hereditary angioedema (HAE), following its July 2025 approval. Key opinion leaders predict the majority of the on-demand market will convert to oral treatment, with potentially 60% of HAE patients using Ekterly at peak, contingent on payor coverage. BofA highlights early 2026 finalized payor policies as a key focus area and projects FY26 sales of $102.8 million, with peak sales reaching $685 million.
In recent developments, KalVista Pharmaceuticals reported preliminary fourth-quarter 2025 global sales for Ekterly of approximately $35 million, significantly exceeding analyst expectations. Several firms, including Stifel and Needham, reiterated Buy ratings following the strong sales figures.
Ocular Therapeutix features as one of BofA’s top small-cap picks for 2026, with a Buy rating and $21 price objective. Analysts anticipate the pivotal SOL-1 topline readout in Q1 2026 will validate Axpaxli’s differentiated long-acting profile in wet age-related macular degeneration (AMD). This readout represents a critical catalyst with implications for the second pivotal study (SOL-R) expected in 1H27. BofA believes Axpaxli has a first-to-market advantage in the long-acting injectable class and models $2.4 billion in nominal peak sales in wet AMD with a projected 2027 launch.
Ocular Therapeutix has reportedly received and rejected a takeover offer from Sanofi, which is said to be preparing a higher bid. The company also appointed David W. Robinson as its new Global Chief Commercial Officer to prepare for the potential launch of Axpaxli.
Vertex Pharmaceuticals rounds out BofA’s top biotech picks for 2026 with a Buy rating and $571 price objective. As the leader in cystic fibrosis (CF), Vertex is actively diversifying its portfolio. BofA identifies the Phase 3 readout for povetacicept (pove) in IgA nephropathy (IgAN) as the key 2026 catalyst, with Vertex planning to submit for accelerated approval in 1H26. Analysts believe pove has best-in-class potential in IgAN and see opportunities for expansion into primary membranous nephropathy (pMN) and generalized myasthenia gravis (gMG). The CF franchise contributes $511/share to BofA’s price objective, with additional upside potential from IgAN developments and continued strong execution from Journavx.
Vertex Pharmaceuticals has received several analyst rating upgrades, including from Morgan Stanley and RBC Capital, who cited a more positive outlook on the company’s kidney franchise pipeline ahead of key clinical trial data expected in 2026.
This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.


























