Pasithea Therapeutics Initiated at Buy by HC Wainwright & Co.

Investing.com – U.S. stocks were higher after the close on Wednesday, as gains in the Basic Materials, Utilities and Consumer Goods sectors led shares higher.

At the close in NYSE, the Dow Jones Industrial Average added 0.67%, while the S&P 500 index added 0.69%, and the NASDAQ Composite index added 0.82%.

The best performers of the session on the Dow Jones Industrial Average were Boeing Co (NYSE:BA), which rose 2.46% or 4.48 points to trade at 186.92 at the close. Meanwhile, Walmart Inc (NYSE:WMT) added 1.97% or 2.10 points to end at 109.10 and Microsoft Corporation (NASDAQ:MSFT) was up 1.78% or 8.51 points to 485.50 in late trade.

The worst performers of the session were Salesforce Inc (NYSE:CRM), which fell 2.55% or 5.97 points to trade at 228.15 at the close. Merck & Company Inc (NYSE:MRK) declined 0.97% or 1.03 points to end at 104.63 and Honeywell International Inc (NASDAQ:HON) was down 0.54% or 1.03 points to 189.99.

The top performers on the S&P 500 were Teradyne Inc (NASDAQ:TER) which rose 6.98% to 179.38, Dell Technologies Inc (NYSE:DELL) which was up 5.83% to settle at 133.26 and Newmont Goldcorp Corp (NYSE:NEM) which gained 4.93% to close at 90.52.

The worst performers were Deere & Company (NYSE:DE) which was down 5.76% to 469.46 in late trade, Intuit Inc (NASDAQ:INTU) which lost 2.94% to settle at 629.02 and ServiceNow Inc (NYSE:NOW) which was down 2.74% to 802.72 at the close.

The top performers on the NASDAQ Composite were Lion Group Holding Ltd (NASDAQ:LGHL) which rose 1,543.33% to 7.12, SMX Security Matters Ord Shs Class A (NASDAQ:SMX) which was up 194.42% to settle at 17.40 and Pasithea Therapeutics Corp (NASDAQ:KTTA) which gained 117.39% to close at 1.06.

The worst performers were Lazydays Holdings Inc (NASDAQ:GORV) which was down 45.31% to 0.42 in late trade, Mingzhu Logistics Holdings Ltd (NASDAQ:YGMZ) which lost 34.15% to settle at 0.12 and Kaixin Auto Holdings (NASDAQ:KXIN) which was down 30.83% to 0.14 at the close.

Rising stocks outnumbered declining ones on the New York Stock Exchange by 1923 to 819 and 94 ended unchanged; on the Nasdaq Stock Exchange, 2108 rose and 1275 declined, while 148 ended unchanged.

Shares in Walmart Inc (NYSE:WMT) rose to all time highs; up 1.97% or 2.10 to 109.10. Shares in Lazydays Holdings Inc (NASDAQ:GORV) fell to all time lows; down 45.31% or 0.35 to 0.42. Shares in Mingzhu Logistics Holdings Ltd (NASDAQ:YGMZ) fell to all time lows; losing 34.15% or 0.06 to 0.12. Shares in Kaixin Auto Holdings (NASDAQ:KXIN) fell to all time lows; down 30.83% or 0.06 to 0.14.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was down 7.33% to 17.20.

Gold Futures for February delivery was up 0.76% or 31.60 to $4,196.80 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in January rose 0.83% or 0.48 to hit $58.59 a barrel, while the February Brent oil contract rose 1.07% or 0.66 to trade at $62.46 a barrel.

EUR/USD was unchanged 0.22% to 1.16, while USD/JPY rose 0.26% to 156.46.

The US Dollar Index Futures was down 0.07% at 99.52.

Investing.com – U.S. stocks were higher after the close on Monday, as gains in the Technology, Consumer Goods and Utilities sectors led shares higher.

At the close in NYSE, the Dow Jones Industrial Average rose 0.44%, while the S&P 500 index climbed 1.55%, and the NASDAQ Composite index climbed 2.69%.

The best performers of the session on the Dow Jones Industrial Average were Merck & Company Inc (NYSE:MRK), which rose 2.70% or 2.64 points to trade at 100.40 at the close. Meanwhile, Amazon.com Inc (NASDAQ:AMZN) added 2.44% or 5.38 points to end at 226.07 and International Business Machines (NYSE:IBM) was up 2.25% or 6.70 points to 304.14 in late trade.

The worst performers of the session were Procter & Gamble Company (NYSE:PG), which fell 2.61% or 3.94 points to trade at 146.98 at the close. Verizon Communications Inc (NYSE:VZ) declined 2.47% or 1.02 points to end at 40.21 and Walt Disney Company (NYSE:DIS) was down 2.25% or 2.35 points to 101.94.

The top performers on the S&P 500 were Broadcom Inc (NASDAQ:AVGO) which rose 11.10% to 377.96, Western Digital Corporation (NASDAQ:WDC) which was up 8.43% to settle at 150.93 and Micron Technology Inc (NASDAQ:MU) which gained 7.99% to close at 223.93.

The worst performers were Carnival Corporation (NYSE:CCL) which was down 6.78% to 24.76 in late trade, Paramount Skydance Corp (NASDAQ:PSKY) which lost 5.22% to settle at 15.06 and Copart Inc (NASDAQ:CPRT) which was down 4.47% to 38.91 at the close.

The top performers on the NASDAQ Composite were Meihua International Medical Technologies Co Ltd (NASDAQ:MHUA) which rose 8,103.58% to 11.93, Antelope Enterprise Holdings Ltd (NASDAQ:AEHL) which was up 108.26% to settle at 2.52 and Pasithea Therapeutics Corp (NASDAQ:KTTA) which gained 48.53% to close at 0.43.

The worst performers were Clearside Biomedical Inc (NASDAQ:CLSD) which was down 66.92% to 0.90 in late trade, Twin Hospitality Group Inc (NASDAQ:TWNP) which lost 39.44% to settle at 2.15 and Mobilehealth Network Solutions (NASDAQ:MNDR) which was down 38.53% to 2.92 at the close.

Rising stocks outnumbered declining ones on the New York Stock Exchange by 1721 to 1034 and 82 ended unchanged; on the Nasdaq Stock Exchange, 2194 rose and 1181 declined, while 153 ended unchanged.

Shares in Copart Inc (NASDAQ:CPRT) fell to 52-week lows; falling 4.47% or 1.82 to 38.91. Shares in Meihua International Medical Technologies Co Ltd (NASDAQ:MHUA) rose to 3-years lows; gaining 8,103.58% or 11.78 to 11.93. Shares in Clearside Biomedical Inc (NASDAQ:CLSD) fell to all time lows; losing 66.92% or 1.82 to 0.90. Shares in Twin Hospitality Group Inc (NASDAQ:TWNP) fell to all time lows; losing 39.44% or 1.40 to 2.15.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was down 12.46% to 20.51.

Gold Futures for February delivery was up 1.21% or 49.70 to $4,165.70 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in January rose 2.02% or 1.17 to hit $58.98 a barrel, while the February Brent oil contract rose 1.42% or 0.88 to trade at $62.82 a barrel.

EUR/USD was unchanged 0.06% to 1.15, while USD/JPY rose 0.33% to 156.90.

The US Dollar Index Futures was up 0.01% at 100.12.

Investing.com -- Pasithea Therapeutics Corp (NASDAQ:KTTA) stock plummeted 25% in after-hours trading Thursday following the release of interim Phase 1 data for its MEK inhibitor PAS-004.

The clinical-stage biotech company reported initial results from its first-in-human trial evaluating PAS-004 in patients with MAPK pathway-driven advanced solid tumors. Despite the company highlighting a partial response in one melanoma patient and a disease control rate of 71.4% in patients with BRAF-mutated tumors, investors appeared unimpressed with the overall efficacy profile.

The trial data showed that among 21 efficacy-evaluable patients, only one achieved a partial response - a BRAF V600E melanoma patient who showed a 31.9% tumor reduction and remains on trial for over 11 months. A second melanoma patient achieved stable disease with minimal tumor shrinkage of 1.6% after six months of treatment.

Pasithea reported that PAS-004 demonstrated a favorable safety profile with all treatment-related adverse events being Grade 1 or 2, with no ocular or cardiovascular toxicities observed. Common side effects included nausea (18.5%), vomiting (14.8%), rash (7.4%), and diarrhea (7.4%).

The company is developing PAS-004 as a potential treatment for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN). The drug showed dose-proportional pharmacokinetics with an AUC of approximately 5,480 ng·h/mL at the 30mg capsule dose.

Despite management’s optimistic interpretation of the data, the significant stock decline suggests investors had expected stronger efficacy signals from this interim readout.

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