Monte Rosa stock rises after promising clinical data in prostate cancer

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Investing.com -- Monte Rosa Therapeutics (NASDAQ:GLUE) stock rose 3.5% after the company announced positive interim data from its...

Investing.com -- Monte Rosa Therapeutics (NASDAQ:GLUE) stock rose 3.5% after the company announced positive interim data from its Phase 1/2 clinical study of MRT-2359 in combination with enzalutamide for treating metastatic castration-resistant prostate cancer (mCRPC).

The clinical-stage biotechnology company reported a 100% PSA response rate and 100% disease control rate in patients with androgen receptor (AR) mutations. Among the four patients with AR mutations, two showed RECIST partial responses while two maintained stable disease. The overall disease control rate across all 14 evaluable patients was 64%.

Monte Rosa’s MRT-2359, an orally bioavailable molecular glue degrader targeting GSPT1, demonstrated a favorable safety profile when combined with enzalutamide. Patients primarily experienced mild to moderate gastrointestinal adverse events (Grade 1-2).

"We continue to be highly encouraged by the clinical activity observed with MRT-2359 in combination with enzalutamide in heavily pretreated mCRPC patients, a population with limited therapeutic options," said Markus Warmuth, CEO of Monte Rosa Therapeutics.

The study population included 20 heavily pretreated individuals with advanced CRPC, with 75% previously treated with a second-generation AR inhibitor, 80% with taxane chemotherapy, and 55% with Pluvicto.

Based on these results, Monte Rosa plans to initiate a new signal-confirming Phase 2 study in 2026, evaluating MRT-2359 in combination with a second-generation AR inhibitor in mCRPC patients with AR mutations. The company expects to present updated data at the ASCO Genitourinary Cancers Symposium in February 2026.

The company also announced plans to present interim Phase 1 data on MRT-8102, its NEK7-directed molecular glue degrader for inflammatory diseases, in early 2026.

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Dj Broadcom Stock Is Getting Stomped. Why It's Still J.P. Morgan's Top Chip Pick. - Barrons.Com

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WongDoody Creates Immersive Experience of Stadium Takeover at NBA and NFL Games with Netflix's Squid Game: The Challenge

Acceswire

The live game activation challenged fans to compete like the players on the hit reality TV show

NEW YORK, NY / ACCESS Newswire / December 16, 2025 / WongDoody, a leading global creative technology agency owned by Infosys, a leader in next‑generation digital services and consulting, today announced the successful activation for the Netflix hit reality series, Squid Game: The Challenge. The live activation featured four major stadium takeovers during NBA and NHL games, bringing the show's intense competition directly to fans to coincide with the season premier. Spectators at the Detroit Pistons, LA Kings, Las Vegas Golden Knights, and Memphis Grizzlies games were challenged on the jumbotron to compete just like the players on the series in Episode 1 of Season 2.

The activation focused on two pre-selected fan sections in each stadium. The Challenge, a segment pulled directly from the show, required one representative from each section to count exactly 45.6 seconds before hitting a buzzer. The closest to 45.6 seconds won the player's entire section a free month of Netflix. Failure resulted in immediate visual "elimination," as the losing section was publicly "inked" on the jumbotron for the crowd to see.

"In close partnership with production teams along with the NBA and NHL staff, our team accelerated this immersive experience from ideation to activation in just 10 weeks," stated Falk Eumann, Executive Creative Director, North America of WongDoody. "This rapid process included developing the core concept, creating all digital assets, and producing the in-game Challenge teaser. By prioritizing fan experience, we successfully built the Squid Game: The Challenge live experience to communicate the new season and maximize fan engagement and ensure each game was a memorable event."

Adding to the takeover's immersive environment, Netflix's Pink Soldiers (or Masked Men) patrolled the stadiums. Dressed in their signature pink jumpsuits and black masks, these Masked Men walked the concourses and stands, engaging with fans to bring the authentic Squid Game atmosphere to the entire arena.

WongDoody develops immersive brand experiences by integrating its key services including Scalable Creative Content Solutions, Digital Twin Marketing, Retail and Live Communications, and NextGen AI Content to maximize audience interaction. Learn more here.

About WongDoody

WongDoody is a global creative technology agency built to help brands move faster, scale smarter, and connect deeper with the people who matter most. As part of Infosys, we combine creativity and technology to deliver intelligent, human-centered experiences at scale. By combining creative excellence with deep technical expertise, we guide our clients through strategy, design, and implementation to deliver end-to-end solutions that create real impact.

With 22 studios and 2,000+ designers and innovators around the world, WongDoody's expertise in human insight and experience design combined with Infosys' AI technology prowess delivers a full end-to-end experience from concept to deployment. Together, we've delivered hundreds of marketing transformation engagements across industries, helping organizations design more engaging experiences that drive profitability and business impact.

For more information, visit https://www.wongdoody.com/ and follow us on LinkedIn and Instagram.

Contact:

pr@wongdoody.com

SOURCE: WongDoody

View the original press release on ACCESS Newswire

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Ford, Kraft Heinz and Circle Internet rise premarket; iRobot slumps

Investing.com

Investing.com -- U.S. stock futures slipped lower Tuesday, with investors cautious ahead of the release of key economic data, including the delayed November jobs report.

Here are some of the biggest premarket U.S. stock movers today:

Ford (NYSE:F) stock rose 1.4% after the auto giant said it will take a $19.5 billion writedown and is killing several electric-vehicle models, in a retreat from battery-powered models.
Pfizer (NYSE:PFE) stock rose 0.8% despite the drugs giant forecasting 2026 profit below expectations as it expects lower sales of its COVID products.
Kraft Heinz (NASDAQ:KHC) stock gained 0.7% after the packaged food giant announced industry veteran Steve Cahillane as its new CEO, ahead of its split into two independent public entities.
Circle Internet (NYSE:CRCL) stock rose 3.5% after Visa announced the launch of USDC settlement in the United States, marking a significant advancement for stablecoin integration in mainstream financial services.
iRobot (NASDAQ:IRBT) stock slumped 20%, adding to the previous session’s 67% slump after the Roomba vacuum-cleaner maker filed for bankruptcy.
Accenture (NYSE:ACN) stock rose 2.1% after Morgan Stanley upgraded its stance on the professional services company to “overweight” from “equal-weight”, saying the stock now trades at a compelling valuation following this year’s pullback.
Cognex (NASDAQ:CGNX) stock climbed 4.3% after Goldman Sachs raised its stance on the software company to “buy” from “sell”, saying organic growth is at an inflection point and margin recovery is underway after several years of underperformance.
Southwest Airlines (NYSE:LUV) stock gained 2.1% after Barclays upgraded the carrier to “overweight” from “equalweight”, citing optimism about the airline’s revamped commercial approach, which now incorporates assigned seating and luggage charges.

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Saudi Arabia stocks lower at close of trade; Tadawul All Share down 1.30%

Investing.com

Investing.com – Saudi Arabia stocks were lower after the close on Tuesday, as losses in the Insurance, Hotels & Tourism and Media & Publishing sectors led shares lower.

At the close in Saudi Arabia, the Tadawul All Share declined 1.30% to hit a new 3-months low.

The best performers of the session on the Tadawul All Share were SNB Capital Funds of REITs Fund Unit (TADAWUL:4338), which rose 4.15% or 0.26 points to trade at 6.52 at the close. Meanwhile, Dar Alarkan Real Estate Development (TADAWUL:4300) added 3.47% or 0.53 points to end at 15.80 and Arabian Drilling Co (TADAWUL:2381) was up 1.53% or 1.45 points to 96.35 in late trade.

The worst performers of the session were CHUBB Arabia Cooperative Insurance (TADAWUL:8240), which fell 5.40% or 1.18 points to trade at 20.66 at the close. Rabigh Refining & Petrochemical Co (TADAWUL:2380) declined 4.76% or 0.35 points to end at 7.00 and Abdullah Saad Mohammed Abo Moati Stationeries Co (TADAWUL:4191) was down 4.23% or 1.82 points to 41.18.

Falling stocks outnumbered advancing ones on the Saudi Arabia Stock Exchange by 286 to 49 and 16 ended unchanged.

Shares in CHUBB Arabia Cooperative Insurance (TADAWUL:8240) fell to 52-week lows; falling 5.40% or 1.18 to 20.66.

Crude oil for February delivery was down 1.54% or 0.87 to $55.80 a barrel. Elsewhere in commodities trading, Brent oil for delivery in February fell 1.47% or 0.89 to hit $59.67 a barrel, while the February Gold Futures contract fell 0.31% or 13.50 to trade at $4,321.70 a troy ounce.

EUR/SAR was unchanged 0.07% to 4.41, while USD/SAR unchanged 0.04% to 3.75.

The US Dollar Index Futures was down 0.20% at 97.76.

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Dj Usa Tech Selloff Slows Premarket, But No Recovery - Market Talk

Reuters

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U.S. Tech Selloff Slows Premarket, But No Recovery — Market Talk

Dow Jones Newswires

Artificial-intelligence related stocks in the U.S. fall premarket, though losses are more muted than past days. Anxiety over AI spending and profitability challenges re-emerged last week after disappointing reports from Oracle and Broadcom, setting off a week of heavy selling. Broadcom edges down 0.3% premarket, following three consecutive days of losses in which it dropped 18% and shed $345.5 billion in market value--the largest three-day market cap decline on record. Oracle drops 0.2%. Elsewhere, CoreWeave--which has dropped 46% in the past six weeks--falls 0.6% premarket. Nvidia is one bright spot, up 0.3% premarket. Futures for the tech-heavy Nasdaq are down 0.2%, as the index fails to recover from three days of falls. (josephmichael.stonor@wsj.com)

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