Jyong Biotech Subsidiary Announces Phase II Clinical Data on Cholesterol and LDH Indicators for MCS-8 (PCP), Indicating Potential in Prostate Cancer Prevention and Metabolic Value

GlobeNewswire

New Taipei City, Taiwan, Jan. 30, 2026 (GLOBE NEWSWIRE) -- Jyong Biotech Ltd. (the “Company” or “Jyong Biotech”), a science-driven biotechnology company based in Taiwan committed to developing and commercializing innovative and differentiated new drugs (plant-derived) mainly specializing in the treatment of urinary system diseases, with an initial focus on the markets of the U.S., the EU and Asia, today announced updated statistical analyses for key blood biochemical markers from its Phase II clinical trial of MCS-8 (PCP) conducted in Taiwan. The results underscore MCS-8’s previously indicated multifaceted clinical and commercial potential beyond its clinical evidence in prostate cancer prevention, showing its potential in helping alleviate high-grade malignancy risk. The data reveals significant new value in metabolic indicators, specifically cholesterol and lactate dehydrogenase (LDH). Building on this momentum, the Company is evaluating the feasibility of expanding MCS-8’s indications to include lipid management, atherosclerosis, and cardiovascular diseases—a strategic move aimed at extending the product’s lifecycle and significantly capturing a broader market share.

The Phase II clinical trial demonstrated that after two years of treatment, subjects receiving MCS-8 showed improved lipid control compared with baseline, including:

A statistically significant reduction in total cholesterol levels (P = 0.036);
A statistically significant increase in serum lactate dehydrogenase (LDH) levels observed in the placebo group (P = 0.024), while no such increase was observed in the MCS-8 group.

LDH is an enzyme widely present in organs and tissues throughout the body, and elevated serum LDH levels are commonly associated with cellular damage or cell death. The absence of LDH elevation in the MCS-8 group suggests that MCS-8 may not be causing damage or death to the cell.

As previously disclosed, the primary efficacy endpoint of the Phase II study showed that, compared with placebo, the MCS-8 group demonstrated a 27.3% reduction in overall prostate cancer incidence. In addition, the incidence of high-grade prostate cancer (Total Gleason Score ≥ 7) was reduced by 17.1% compared with placebo. Further pathological analyses demonstrated favorable trends, including a 35.2% reduction in the percentage of positive cores involved at diagnosis and a 24.4% reduction in the percentage of cancer-positive area involved in positive cores, compared with placebo, suggesting improved control of disease progression. Safety data from the previously disclosed analyses showed that long-term administration of MCS-8 for two years did not increase the rate of adverse events. No serious adverse events related to MCS-8 were observed, and no negative effects were identified on liver function, kidney function, or blood pressure. Company believes that the favorable tolerability profile supports the potential suitability of MCS-8 for long-term preventive use.

MCS-8 is developed using Jyong Biotech’s core patented pharmaceutical composition technology, which Company believes significantly enhances bioavailability and improves physiological efficacy, offering substantial potential for the development of multiple dosage forms and indications.

Related research findings have been published in the international journal Nanotechnology and included by Global Medical Discovery institutions in Canada.

MCS-8 remains an investigational new drug candidate and has not been approved for commercial use in any jurisdiction.

About Jyong Biotech Ltd.

Headquartered in Taiwan, Jyong Biotech Ltd. is a science-driven biotechnology company committed to developing and commercializing innovative and differentiated new drugs (plant-derived), mainly specializing in the treatment of urinary system diseases, with an initial focus on the markets of the U.S., the EU and Asia. Since its inception in 2002, the Company has built integrated capabilities that encompass all key functionalities of drug development, including early-stage drug discovery and development, pharmacology, toxicology, clinical trials, regulatory affairs, manufacturing, and commercialization. Leveraging strong research and development capabilities and a proprietary platform, the Company has been developing a series of botanical drug candidates, including its primary botanical drug candidate, BOTRESO®, another clinical-stage botanical drug candidate, and other preclinical-stage botanical drug candidates. The Company endeavors to develop and supply first-class innovative drugs to meet customers’ health needs and seeks to be a valuable business organization that is held in high esteem by the public.

For more information, please visit: https://www.jyongbio.com/, https://jyongir.com/.

Forward-Looking Statement

This press release contains forward-looking statements. Forward-looking statements include statements concerning plans, objectives, goals, strategies, future events or performance, and underlying assumptions and other statements that are other than statements of historical facts. When the Company uses words such as “may, “will, “intend,” “should,” “believe,” “expect,” “anticipate,” “project,” “estimate” or similar expressions that do not relate solely to historical matters, it is making forward-looking statements. Forward-looking statements are not guarantees of future performance and involve risks and uncertainties that may cause the actual results to differ materially from the Company's expectations discussed in the forward-looking statements. These statements are subject to uncertainties and risks including, but not limited to, the uncertainties related to market conditions and other factors discussed in the “Risk Factors” section of the registration statement, prospectuses, annual and interim reports, and other filings with the SEC. For these reasons, among others, investors are cautioned not to place undue reliance upon any forward-looking statements in this press release. Additional factors are discussed in the Company's filings with the SEC, which are available for review at www.sec.gov. The Company undertakes no obligation to publicly revise these forward-looking statements to reflect events or circumstances that arise after the date hereof.

For more information, please contact:

Jyong Biotech Ltd.

ir@jyongbio.com

Investor Relations

WFS Investor Relations Inc.

Email: services@wealthfsllc.com

Phone: +1 628 283 9214

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Micron Tech and Nike among market cap stock movers on Wednesday

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Edgewise Therapeutics

+3.23%

UiPath

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Wednesday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Micron Tech and Nike are rallying, while others like New Providence Acquisition Corp N are falling. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers (Market Cap:$200B+ USD)

Micron Tech (MU) +3.77%
Costco Whsl Corp New (COST) +2.0%

Large-Cap Stock Movers (Market Cap:$10-$200B USD)

Nike (NKE) +4.64%
DPCM Capital (QBTS) -5.56%
New Providence Acquisition Corp N (ASTS) -8.89%
Amark Preci (GOLD) +3.11%

Mid-Cap Stock Movers (Market Cap:$2-$10B USD)

Edgewise Therapeutics (EWTX); Edgewise reports positive interim safety data for HCM drug EDG-7500 +25.5%
Retrophin I (TVTX) +13.91%
Uipath (PATH) +7.46%
Grupo Aeromexico (AERO) +6.07%
CF Acquisition Corp VI (RUMBW) +6.5%
Mudrick Capital A (HYMC) -8.03%

Small-Cap Stock Movers (Market Cap:$300M-$2B USD)

Omeros Corp (OMER); FDA approves Omeros’ Yartemlea for stem cell transplant complication +75.54%
Dynavax Tech (DVAX); Sanofi to acquire Dynavax for $2.2 billion in cash deal +38.19%
Thunder Bridge Capital Partners IV (CNCK) +19.53%
Agios Pharm (AGIO); FDA approves Agios’ AQVESME for thalassemia anemia treatment +18.63%
Phoenix Asia Holdings (PHOE) +14.81%
Polestar Automotive Holding Plc (PSNY) +13.55%
Kodiak Sciences Inc (KOD) +13.22%
ZKH ADR (ZKH) +12.07%
Aspirational Consumer Lifestyle (UP) +12.11%
Jyong Biotech (MENS) -11.44%

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nvidia and avago among market cap stock movers on Tuesday

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BitMine Immersion Technologies, Inc.

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Jyong Biotech Ltd.

-4.29%

Tuesday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Regencell Bioscience Holdings (RGC) are rallying, while stocks like Oracle Corp (ORCL) are falling. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers ($200 billion USD or higher)

Nvidia Corp (NVDA) +2.68%
Avago Technologies (AVGO) +2.22%
Oracle Corp (ORCL) -2.15%

Large-Cap Stock Movers ($10-$200 billion USD)

Regencell Bioscience Holdings (RGC) +15.3%
Venture Global Inc (VG) +3.86%
DPCM Capital (QBTS) -9.2%
Moderna (MRNA) -6.3%
First Solar Inc (FSLR) -6.43%
Circle Internet Group Inc (CRCL) -5.87%
Bitmine Immersion Tech (BMNR) -5.24%
Affirm Holdings (AFRM) -4.52%
Unity Software Inc (U) -3.94%

Mid-Cap Stock Movers ($2-$10 billion USD)

Grupo Simec BATS (SIM) +13.05%
Structure Therapeutics ADR (GPCR) +10.75%
Lionsgate Studios Holding (LION) +7.34%
ZIM Integrated Shipping Services (ZIM) +6.88%; ZIM shipping evaluates acquisition offers amid strategic review
B Riley Principal Merger Ii (EOSE) -7.02%; Eos Energy board chair Stidolph steps down, Nigro to take over
Fly Leasing Ltd (FLY) -7.38%
Via Transportation Ltd (VIA) -7.48%
Asana Inc (ASAN) -6.43%
NantKwest (IBRX) -8.45%
Cantor Equity Partners Class A (XXI) -9.45%

Small-Cap Stock Movers ($300 million - $2 billion USD)

Flame Acquisition (SOC) +31.58%
Mudrick Capital A (HYMC) +16.4%
NovaBay Pharmaceuticals Inc (NBY) -15.29%
TryHard Holdings (THH) -18.79%
Jyong Biotech (MENS) -11.53%
Gossamer Bio Inc (GOSS) -11.27%
Rxsight (RXST) -11.73%
Canadian Solar (CSIQ) -12.09%
Velo3D (VELO) -8.53%
Starfighters Space (FJET) -54.76%; Starfighters Space provides corporate update after NYSE American listing

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Applovin, Oracle among market cap stock movers on Tuesday

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ZIM Integrated Shipping

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Tuesday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Applovin and Oracle are experiencing declines. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers (Market Cap:$200 billion USD or higher)

Applovin (APP) -3.03%
Oracle Corp (ORCL) -2.11%

Large-Cap Stock Movers (Market Cap:$10-$200 billion USD)

First Solar Inc (FSLR) -5.4%
Circle Internet Group Inc (CRCL) -5.3%
Robinhood Markets (HOOD) -3.38%
DPCM Capital (QBTS) -3.98%
Unity Software Inc (U) -3.63%
Wayfair Inc (W) -3.49%
Xpeng Inc (XPEV) -3.15%
Joby Aviation (JOBY) -2.6%
Credo Technology Holding (CRDO) -2.05%
Bitmine Immersion Tech (BMNR) -4.55%

Mid-Cap Stock Movers (Market Cap:$2-$10 billion USD)

Asana Inc (ASAN) -5.7%
Uipath (PATH) -5.24%
Sustainable Opportunities Acqui (TMC) -4.93%
B Riley Principal Merger Ii (EOSE); Eos Energy board chair Stidolph steps down, Nigro to take over -4.65%
Applied Blockchain (APLD) -4.03%
NantKwest (IBRX) -5.29%
StoneCo Ltd (STNE) +6.08%
ZIM Integrated Shipping Services (ZIM); ZIM shipping evaluates acquisition offers amid strategic review +6.99%
Century Aluminum Co (CENX) +3.6%
Lionsgate Studios Holding (LION) +8.25%

Small-Cap Stock Movers (Market Cap:$300 million -$2 billion USD)

Starfighters Space (FJET); Starfighters Space provides corporate update after NYSE American listing -44.25%
NovaBay Pharmaceuticals Inc (NBY) -14.18%
Rxsight (RXST) -12.59%
Ares Acquisition oration II (KDK) -9.42%
Aclaris Therapeutics Inc (ACRS) -8.96%
Jyong Biotech (MENS) -8.79%
Uxin (UXIN) -7.83%
Intrexon Corpn (PGEN) -5.59%
Flame Acquisition (SOC) +19.26%
GoGreen Investments (LZM) +11.4%

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U.S. stocks lower at close of trade; Dow Jones Industrial Average down 0.47%

Investing.com

GE Vernova LLC

-0.02%

Vision Marine Technologies

Processa Pharmaceuticals

-3.36%

Investing.com – U.S. stocks were lower after the close on Wednesday, as losses in the Technology, Consumer Goods and Industrials sectors led shares lower.

At the close in NYSE, the Dow Jones Industrial Average lost 0.47%, while the S&P 500 index declined 1.16%, and the NASDAQ Composite index lost 1.81%.

The best performers of the session on the Dow Jones Industrial Average were Chevron Corp (NYSE:CVX), which rose 1.89% or 2.77 points to trade at 149.52 at the close. Meanwhile, Procter & Gamble Company (NYSE:PG) added 1.79% or 2.60 points to end at 147.81 and McDonald’s Corporation (NYSE:MCD) was up 1.33% or 4.19 points to 318.69 in late trade.

The worst performers of the session were Caterpillar Inc (NYSE:CAT), which fell 4.58% or 26.97 points to trade at 561.96 at the close. NVIDIA Corporation (NASDAQ:NVDA) declined 3.83% or 6.80 points to end at 170.92 and Nike Inc (NYSE:NKE) was down 2.06% or 1.38 points to 65.74.

The top performers on the S&P 500 were Devon Energy Corporation (NYSE:DVN) which rose 5.30% to 36.95, FMC Corporation (NYSE:FMC) which was up 4.71% to settle at 13.78 and ConocoPhillips (NYSE:COP) which gained 4.65% to close at 94.99.

The worst performers were GE Vernova LLC (NYSE:GEV) which was down 10.50% to 614.19 in late trade, Vistra Energy Corp (NYSE:VST) which lost 7.77% to settle at 159.97 and Generac Holdings Inc (NYSE:GNRC) which was down 6.78% to 144.82 at the close.

The top performers on the NASDAQ Composite were Mega Fortune Co Ltd (NASDAQ:MGRT) which rose 143.93% to 13.05, Processa Pharmaceuticals Inc (NASDAQ:PCSA) which was up 122.30% to settle at 6.68 and Agape ATP Corp (NASDAQ:ATPC) which gained 56.44% to close at 0.14.

The worst performers were Jyong Biotech Ltd (NASDAQ:MENS) which was down 81.04% to 2.92 in late trade, VistaGen Therapeutics Inc (NASDAQ:VTGN) which lost 80.25% to settle at 0.86 and Vision Marine Technologies Inc (NASDAQ:VMAR) which was down 49.46% to 0.49 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 1483 to 1239 and 107 ended unchanged; on the Nasdaq Stock Exchange, 2226 fell and 1127 advanced, while 184 ended unchanged.

Shares in Mega Fortune Co Ltd (NASDAQ:MGRT) rose to all time highs; gaining 143.93% or 7.70 to 13.05. Shares in Jyong Biotech Ltd (NASDAQ:MENS) fell to all time lows; losing 81.04% or 12.48 to 2.92. Shares in VistaGen Therapeutics Inc (NASDAQ:VTGN) fell to all time lows; losing 80.25% or 3.50 to 0.86.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was up 6.92% to 17.62.

Gold Futures for February delivery was up 1.03% or 44.45 to $4,376.75 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in February rose 2.94% or 1.62 to hit $56.75 a barrel, while the February Brent oil contract rose 2.87% or 1.69 to trade at $60.61 a barrel.

EUR/USD was unchanged 0.06% to 1.17, while USD/JPY rose 0.66% to 155.73.

The US Dollar Index Futures was up 0.24% at 98.03.

Risk Warnings and Disclaimers

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Avago and Oracle among market cap stock movers on Wednesday

Investing.com

Recursion Pharmaceuticals

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Wednesday’s market has seen notable movements in various stocks due to news and other factors. Today, stocks like Avago Technologies and Oracle are experiencing declines, while others show mixed performances. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers (Market Cap:$200 billion USD and above)

Oracle Corp (ORCL); Blue Owl will not back $10B deal for Oracle data center - FT; -5.02%
Avago Technologies (AVGO) -5.2%
Lam Research Corp (LRCX) -5.05%
Caterpillar (CAT) -4.73%
Adv Micro Device ( -4.81%
Palantir Technologies Inc (PLTR) -4.33%
Tesla Motors (TSLA) -4.44%
Applied Matls Inc (AMAT) -3.77%
Micron Tech (MU) -3.72%
Nvidia Corp (NVDA) -3.35%

Large-Cap Stock Movers (Market Cap:$10-$200 billion USD)

Medline Inc (MDLN) +30.95%
Bloom Energy Corp (BE) -10.78%
GE Vernova LLC (GEV) -8.66%
Comfort Systems USA Inc (FIX) -8.06%
nVent Electric (NVT) -8.34%
Constellation Energy Group-Exch (CEG) -8.13%
AltC Acquisition (OKLO); Oklo conducts plutonium reactor tests with Los Alamos lab; -7.51%
New Providence Acquisition Corp N (ASTS) -7.28%
Vistra Energy Corp (VST) -7.26%
Texas Pacific Land Trust (TPL); Texas Pacific Land partners with Bolt Data & Energy for data centers; +6.98%

Mid-Cap Stock Movers (Market Cap:$2-$10 billion USD)

Recursion Pharmaceuticals (RXRX); Recursion Pharmaceuticals stock upgraded by JPMorgan on MEK inhibitor potential; +17.39%
Hut 8 Mining PK (HUT); Hut 8 partners with Anthropic to deploy up to 2,295 MW of AI infrastructure; +11.75%
Immunome Inc (IMNM); Immunome prices public offering of common stock at $21.50 per share; -11.01%
Sterling Construc (STRL) -10.15%
Fluence Energy (FLNC) -10.23%
Fermi America LLC (FRMI) -10.03%
EverCommerce (EVCM) -10.0%
Ikonics Corp (WULF) -9.89%
Modine Manufacturing Comp (MOD) -8.65%
Integrated Electr (IESC) -8.48%

Small-Cap Stock Movers (Market Cap:$300 million - $2 billion USD)

Jyong Biotech (MENS) -75.34%
Kyverna Therapeutics (KYTX); Kyverna Therapeutics prices public offering of common stock at $7.50; -31.49%
Thunder Bridge Capital Partners IV (CNCK) -28.57%
NuStar GP Holdings LLC (SPIR) -24.92%
Andersen Group Corp (ANDG) +27.31%
Dingdong ADR (DDL) +23.3%
Udemy (UDMY) +17.6%
4D Molecular Therapeutics (FDMT) -15.1%
Armada Acquisition I (RZLV) -17.68%
Kodiak Sciences Inc (KOD); Kodiak Sciences prices upsized public offering at $160 million; +11.73%

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Oracle and Shopify among market cap stock movers on Wednesday

Investing.com

Wednesday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Oracle and Shopify are experiencing significant movements. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers

(Market Cap:$200 billion USD or higher)

Oracle (ORCL); Blue Owl will not back $10B deal for Oracle data center - FT; -4.8%
Avago Technologies (AVGO); -2.65%
Nvidia (NVDA); -1.87%
Salesforce Com (CRM); BTIG initiates coverage on Salesforce stock with Buy rating, $335 target; +2.72%
Netflix (NFLX); Warner to Reject Paramount Offer As Soon As Wednesday, Sources Say -- WSJ; +2.69%
Shopify (SHOP); +4.19%

Large-Cap Stock Movers

(Market Cap:$10-$200 billion USD)

Soc Quimica ADR (SQM); Sociedad Quimica y Minera stock rating upgraded by JPMorgan on lithium outlook; +7.32%
Texas Pacific Land Trust (TPL); Texas Pacific Land partners with Bolt Data & Energy for data centers; +7.39%
Nutanix Inc (NTNX); +6.64%
Albemarle (ALB); +5.05%
Moderna (MRNA); +4.72%
Jabil Circuit (JBL); +4.02%
Astera Labs (ALAB); +3.22%
Lumentum Holdings Inc (LITE); +3.16%
Vistra Energy Corp (VST); -3.85%
Celsius Holdings (CELH); -5.11%

Mid-Cap Stock Movers

(Market Cap:$2-$10 billion USD)

Recursion Pharmaceuticals (RXRX); Recursion Pharmaceuticals stock upgraded by JPMorgan on MEK inhibitor potential; +17.75%
Hut 8 Mining PK (HUT); Hut 8 partners with Anthropic to deploy up to 2,295 MW of AI infrastructure; +16.05%
Toro Co. (TTC); Toro shares jump as company beats estimates, raises 2026 guidance; +8.38%
Alpha Metallurgical Resources (AMR); +5.01%
Kensington Capital Acquisition (QS); QuantumScape signs joint development deal with top-10 global automaker; +4.38%
Cantor Equity Partners Class A (XXI); +5.59%
Good Works Acquisition (CIFR); +3.84%
WeShop Holdings Ltd (WSHP); WeShop adds Dick’s Sporting Goods, GNC among new retail partners; -13.7%
Immunome Inc (IMNM); Immunome prices public offering of common stock at $21.50 per share; -10.63%

Small-Cap Stock Movers

(Market Cap:$300 million - $2 billion USD)

Udemy (UDMY); +24.49%
Dingdong ADR (DDL); +17.11%
Mudrick Capital A (HYMC); +16.06%
Uniqure Nv (QURE); +13.57%
Kodiak Sciences Inc (KOD); Kodiak Sciences prices upsized public offering at $160 million; +12.87%
New Fortress Energy LLC (NFE); New Fortress Energy extends forbearance agreement with noteholders; +11.54%
Lion Biotechnologies (IOVA); +8.22%
Kyverna Therapeutics (KYTX); Kyverna Therapeutics prices public offering of common stock at $7.50; -29.0%
NuStar GP Holdings LLC (SPIR); -21.47%
Jyong Biotech (MENS); -34.03%