Adaptive Biotechnologies to Report Fourth Quarter and Full Year 2025 Financial Results on February 5, 2026

Monday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Alibaba and Pure Storage are rallying, while others such as American Express and Synchrony Financial are seeing declines. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers (Market Cap:$200 billion USD or higher)

• Alibaba (BABA) +8.92%
• Wal-Mart Stores (WMT) +2.21%
• Visa Inc (V) -2.33%
• Mastercard Cl A (MA) -2.34%
• Disney (DIS) -2.45%
• Intuitive Surgical Inc (ISRG) -2.81%
• Citigroup (C) -3.4%
• American Express (AXP) -5.29%
• Applovin (APP) -1.35%

Large-Cap Stock Movers (Market Cap:$10-$200 billion USD)

• CoreWeave (CRWV); Goldman Sachs initiates CoreWeave stock coverage with Neutral rating +9.6%
• Hecla Mining Comp (HL) +9.02%
• Pure Storage Inc (PSTG) +8.85%
• Tempus AI (TEM); Northwestern Medicine and Tempus partner to expand cancer genomic testing +8.22%
• Coeur dAlene Mines Corp (CDE) +7.43%
• Regencell Bioscience Holdings (RGC) +3.47%
• Summit Therapeutics PLC (SMMT) -15.19%
• Alnylam Pharmaceuticals (ALNY) -8.51%
• Synchrony Fin (SYF) -8.62%
• Affirm Holdings (AFRM) -7.6%

Mid-Cap Stock Movers (Market Cap:$2-$10 billion USD)

• Beam Inc. (BEAM) +24.59%
• Kingsoft Cloud Holdings Ltd (KC) +19.78%
• Mudrick Capital A (HYMC) +16.03%
• Adaptive Biotechnologies Corp (ADPT); Adaptive Biotechnologies reports 55% revenue growth in 2025 +11.74%
• Panacea Acquisition (NUVB); Eisai to license taletrectinib for ROS1+ lung cancer across Europe, Asia -17.48%
• Apellis Pharma (APLS) -14.58%
• Urban Outfitters (URBN); Urban Outfitters reports 9% sales growth for holiday period -11.89%
• Alphatec Holdings (ATEC); ATEC gains exclusive US rights to OsteoAdapt bone graft technology -20.77%
• Aberc Fitch A (ANF) -18.39%
• NovaBay Pharmaceuticals Inc (NBY) -32.02%

Small-Cap Stock Movers (Market Cap:$300 million-$2 billion USD)

• Aspirational Consumer Lifestyle (UP) +38.74%
• Zenas Biopharma (ZBIO) +20.65%
• Dot Therapeutics2 (DAWN) +18.68%
• Bioage Labs Inc (BIOA) +17.14%
• SunOpta (STKL) +17.61%
• Rxsight (RXST) +15.16%
• Caredx Inc (CDNA); CareDx reports 25% revenue growth in Q4, expects $380 million for 2025 +14.21%
• Tocagen Inc (FBRX) +24.5%
• Lexeo Therapeutics (LXEO); Lexeo’s gene therapy shows promising results for heart condition -34.06%
• Stoke Therapeutics Inc (STOK) -18.72%

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This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

Investing.com -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) stock surged 16% in pre-market trading Monday after the company reported preliminary fourth quarter revenue that significantly exceeded analyst expectations.

The commercial stage biotechnology company announced unaudited fourth quarter revenue of approximately $72 million, representing a 51% increase compared to the same period in 2024 and well above the consensus estimate of $59.4 million. Full-year 2025 revenue reached approximately $277 million, up 55% YoY and exceeding analyst expectations of $265 million.

The company’s Minimal Residual Disease (MRD) segment drove much of the growth, with fourth quarter MRD revenue reaching approximately $62 million, a 54% increase from the previous year. For the full year, MRD revenue grew 46% to $212 million compared to 2024.

Testing volume for the company’s clonoSEQ product showed strong momentum, with approximately 30,000 tests delivered in the fourth quarter, up 43% from the same period in 2024. The company delivered approximately 105,600 tests for the full year, representing a 39% increase YoY.

"2025 was a pivotal year for Adaptive, marked by accelerating momentum across our MRD business driven by strong growth in clonoSEQ adoption," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies.

The company reported cash, cash equivalents and marketable securities of approximately $227 million as of December 31, 2025, excluding Digital Biotechnologies, Inc. cash and cash equivalents.

Adaptive Biotechnologies plans to release complete fourth quarter and full year 2025 financial results during its earnings call in February 2026.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

Investing.com -- Adaptive Biotechnologies Corp (NASDAQ:ADPT) stock rose 4.3% in Monday premarket trading following the announcement of two non-exclusive agreements with Pfizer Inc (NYSE:PFE) that could be worth up to $890 million.

The commercial stage biotechnology company revealed a target discovery agreement to identify disease-specific T-cell receptors (TCRs) in rheumatoid arthritis and a data licensing agreement for Pfizer to access Adaptive’s proprietary TCR-antigen datasets for research and development in multiple immunology applications.

Under the rheumatoid arthritis agreement, Adaptive will lead target discovery activities to identify disease-specific RA TCRs, while Pfizer will handle all development and commercialization of therapies identified through this work. Adaptive will receive an upfront payment and may be eligible for additional payments in data delivery, development, commercial, and sales milestones potentially totaling up to $890 million.

The second agreement involves Pfizer licensing certain Adaptive TCR-antigen data to develop and train AI and machine learning models for accelerating research and drug discovery across multiple disease areas. For this non-exclusive, multi-year data access agreement, Adaptive will receive an upfront payment and potential future annual licensing fees, though specific financial terms were not disclosed.

Adaptive has generated what it describes as the largest and highest quality TCR-antigen binding dataset compared to what is publicly available, which can potentially inform discoveries across immunology programs.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

Friday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Salesforce (CRM) and Micron Tech (MU) are rallying, while stocks like Netflix (NFLX) are falling. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers (Market Cap:$200 billion USD or higher)

• Salesforce (CRM) +5.46%
• Micron Tech (MU) +5.25%
• General Electric (GE) -2.84%
• Netflix (NFLX); Paramount mulls taking offer straight to WBD shareholders - CNBC -3.5%
• Avago Technologies (AVGO) +2.02%

Large-Cap Stock Movers (Market Cap:$10-$200 billion USD)

• Rubrik (RBRK) +24.95%
• Samsara (IOT); Samsara beats Q3 expectations with 29% revenue growth, shares slip +13.29%
• Ulta Salon Cosmetics & Fragrance (ULTA) +12.56%
• Dollar Tree Inc (DLTR) +8.05%
• Cooper Companies Inc (COO); CooperCompanies names Colleen Jay as new board chair effective January +7.1%
• Dollar General Corp (DG) +7.0%
• Roku (ROKU); Roku CFO to present at Nasdaq investor conference in London +6.91%
• Xp Inc (XP) -8.92%
• DocuSign Inc (DOCU) -7.1%
• Social Capital Hedosophia V (SOFI); SoFi announces $1.5 billion common stock offering -6.74%

Mid-Cap Stock Movers (Market Cap:$2-$10 billion USD)

• Praxis Precision Medicines Inc (PRAX); Praxis’s epilepsy drug trial stopped early after positive results +30.55%
• ServiceTitan (TTAN); ServiceTitan selected as core platform for expanding roofing companies +14.41%
• Victoria’s Secret Co (VSCO) +13.11%
• Terns Pharmaceuticals (TERN) +9.47%
• Parsons Corp (PSN); Parsons stock downgraded by Raymond James after losing FAA contract -22.46%
• Argan (AGX); Argan shares plunge over 10% on top-line miss in Q3 -14.42%
• Adaptive Biotechnologies Corp (ADPT) -13.97%
• SentinelOne (S); SentinelOne shares slide 6% on weak Q4 revenue guidance -13.29%
• Cinemark Hldg (CNK) -8.8%
• MTech Acquisition A (ABTC) -9.28%

Small-Cap Stock Movers (Market Cap:$300 million - $2 billion USD)

• Northstar At Mgt (DBRG); DigitalBridge Group (DBRG) resumes trading, up 32% on Softbank rumor +43.16%
• Alumis (ALMS) +31.01%
• Agencia Comercial Spirits Ltd (AGCC) +22.24%
• Smith & Wesson (SWBI) +22.05%
• Helix Acquisition II (BBOT); Morgan Stanley initiates coverage on BridgeBio Oncology stock with Overweight rating +21.26%
• New Fortress Energy LLC (NFE); New Fortress Energy secures 7-year gas supply deal for Puerto Rico +15.71%
• Immatics NV (IMTX) -12.13%
• Compass Diversified Holdings (CODI) -22.49%
• Domo Inc (DOMO); Domo shares tumble 17% as Q3 results fail to impress -23.69%
• Ambitions Enterprise Management Co (AHMA) -37.61%

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This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

Friday’s market has seen swings in various stocks based on news and other factors. Today, stocks like Salesforce (CRM) and Rubrik (RBRK) are rallying, while stocks like WR Berkley (WRB) and DocuSign (DOCU) are falling. Below are highlights of some of the biggest stock movers, from mega-caps to small caps.

Mega-Cap Movers ($200 billion USD or higher)

• Salesforce (CRM) +4.31%
• Micron Technology (MU) +3.24%
• Advanced Micro Devices ( +2.39%
• Avago Technologies (AVGO) +1.96%

Large-Cap Stock Movers ($10-$200 billion USD)

• Rubrik (RBRK) +26.65%
• Samsara (IOT); Samsara beats Q3 expectations with 29% revenue growth, shares slip +15.08%
• Ulta Salon Cosmetics & Fragrance (ULTA) +13.56%
• Albemarle (ALB); Albemarle stock rating upgraded by UBS on lithium market deficit forecast +7.51%
• Cooper Companies Inc (COO); CooperCompanies names Colleen Jay as new board chair effective January +8.17%
• Lattice Semiconductor (LSCC); Lattice Semiconductor announces $250 million share repurchase program +5.57%
• Social Capital Hedosophia V (SOFI); SoFi prices $1.5 billion public offering of common stock -5.71%
• AltC Acquisition (OKLO); Needham initiates Oklo stock with Buy rating, $135 price target -5.65%
• DocuSign Inc (DOCU) -6.16%
• WR Berkley Corp (WRB); Mitsui Sumitomo acquires 12.5% stake in W. R. Berkley -7.46%

Mid-Cap Stock Movers ($2-$10 billion USD)

• Praxis Precision Medicines Inc (PRAX); Praxis Precision Medicines advances toward NDA submission for tremor drug +43.41%
• Victoria’s Secret Co (VSCO) +17.69%
• Vera Therapeutics (VERA) +5.06%
• Parsons Corp (PSN); Parsons stock downgraded by Raymond James after losing FAA contract -22.28%
• Argan (AGX); Argan shares plunge over 10% on top-line miss in Q3 -13.77%
• SentinelOne (S); SentinelOne shares slide 6% on weak Q4 revenue guidance -10.11%
• Adaptive Biotechnologies Corp (ADPT) -9.82%
• CleanSpark (CLSK) -4.76%
• Cinemark Hldg (CNK) -4.74%

Small-Cap Stock Movers ($300 million - $2 billion USD)

• Ambitions Enterprise Management Co (AHMA) -32.65%
• Domo Inc (DOMO); Domo shares tumble 17% as Q3 results fail to impress -19.27%
• Immatics NV (IMTX) -15.46%
• Compass Diversified Holdings (CODI) -12.26%
• Alumis (ALMS) +20.84%
• Smith & Wesson (SWBI) +17.06%
• New Fortress Energy LLC (NFE); New Fortress Energy secures 7-year gas supply deal for Puerto Rico +16.79%
• Dingdong ADR (DDL) +10.26%
• Pepco Holdings Inc-Exch (POM) +10.65%
• Borr Drilling Ltd (BORR) +9.04%

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This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.